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张蔚

邮  箱: weizhangvv (AT) pku.edu.cn

职  称:研究员

办公室电话:62767697

办公室地址:北京市海淀区颐和园路5号,北京大学,金光生命科学大楼,100871

所属实验室:张蔚实验室

实验室电话:62767697

实验室地址:北京市海淀区颐和园路5号,北京大学,金光生命科学大楼,100871

实验室主页

https://www.weizhanglab.net/

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  • 个人简介
  • 科研领域
  • 代表性论文

教育经历:

2005-2011 博士,北京大学生命科学学院
2001-2005 学士,山东大学生命科学学院

工作经历:

2024-至今 研究员(长聘) 北京大学生命科学学院
2024-至今 研究员(长聘) 北大清华生命科学联合中心
2018年-2024 研究员 北京大学生命科学学院
2018年-2024 研究员 北大清华生命科学联合中心
2012年-2017年 博士后 芝加哥大学生态与演化系
2012年 博士后 芝加哥大学儿科系

荣誉奖励:

生物医学峰基金,2023
国家杰出青年科学基金,2023
北京大学教学优秀奖,2023
本源公益基金,2023
北京大学生命科学学院最受欢迎教师,2022
黄廷方/信和青年杰出学者奖,2022
北京大学第二十一届青年教师教学基本功比赛,一等奖、最佳教案奖、最佳教学演示奖、最受学生欢迎奖,2021
绿叶生物医药杰出青年学者,2020
北京市杰出青年科学基金,2019
博雅青年学者,2019
億方学者,2019
北京市普通高校本科毕业设计优秀指导教师,2019
北京大学优秀班主任,2019
国家高层次人才引进计划(青年项目),2018
芝加哥大学博士后联合会奖学金,2014

学术任职:

2022年-至今 中国昆虫学会 理事
2019年-至今 中国昆虫学会青年工作委员会 委员
2019年-至今 中国昆虫学会昆虫基因组学专业委员会 委员
2021年-至今 中国昆虫学会蛾类专业委员会 委员
2022年-至今 中国昆虫学会蝴蝶分会 委员
2021年-至今 中国动物学会生物进化理论专业委员会 副主任委员
2024年-至今 北京昆虫学会 理事
2019年-至今 西藏自治区科学探险协会 副理事长
2021年-至今 蛋白质与植物基因研究国家重点实验室 学术秘书

执教课程:

现代生物学理论基础-演化与组学(研、SLS),春季
文献深度分析讨论课程-演化与组学(研、SLS),春季
进化和群体遗传学的概念、方法与前沿(本研、SLS),秋季
生态学与演化生物学科研实践(本),春季、秋季
生物演化(通选课),秋季
生态学科研规范与毕业论文(本),讲课,春季
生物信息学(研、PTN),讲课,春季
学位论文写作规范(研、SLS),讲课,春季
研究生科学研究规范训练 (研),讲课,秋季
高级发育生物学(研、CLS),讲课,秋季
遗传学基础(研、CLS),讲课,秋季
      我们的研究兴趣在于整合实验和计算生物学的研究方法,探究重要演化问题的理论基础和分子机理,例如物种形成,适应性性状以及渗入演化。我们的研究对象通常具有物种丰富,适应性辐射以及不完全生殖隔离等特点。例如,鳞翅目昆虫物种丰富,存在广泛种间杂交,并且具有多样的翅膀花纹,是用于研究适应性演化的经典体系。测序技术和基因编辑技术的迅速发展,使得对于非模式生物在全基因组层面进行演化基因组学和群体遗传学研究以及进行目标基因的功能鉴定成为可能。我们的主要研究方向包括:叶形拟态的起源和遗传机制;鳞翅目昆虫发育过程的雌雄二型;适应性基因渐渗的鉴定,功能研究和演化模型等。
(* equal contribution, # corresponding author)
Huang G*, Zhang Y*, Zhang W, Wei F#. Genetic mechanisms of animal camouflage: an interdisciplinary perspective. Trends Genet. 2024 Apr 20:S0168-9525(24)00073-8.

Zhang LJ#*, Shi ZA*, Chen ZY, von Rintelen T, Zhang W, Lou ZJ. Rediscovery and systematics of the enigmatic genus Helicostoa reveals a new species of sessile freshwater snail with remarkable sexual dimorphism. Proc. R. Soc. Lond. B Biol. Sci. Jan 10;291(2024):20231557.

Zhang W#, Lohman DJ. Uncovering the functional basis of mantids that resemble plants. Sci. China Life Sci. 2024 Jan;67(1):215-216.

Yang W, Cui J, Chen Y, Wang C, Yin Y, Zhang W, Liu S, Sun C, Li H, Duan Y, Song F, Cai W, Hines HM, Tian L#. Genetic modification of a Hox locus drives mimetic color pattern variation in a highly polymorphic bumble bee. Mol. Biol. Evol. 2023 Dec 1:msad261.

Teng D, Zhang W#. The diversification of butterfly wing patterns: Progress and prospects. Curr. Opin. Insect Sci. 2023 Nov 3:61:101137. (Invited review)

Wang Z*, Sun J*, Gao Y, Xue Y, Zhang Y, Li K, Zhang W, Zhang C, Zu J#, Zhang L#. Fusang: A framework for phylogenetic tree inference via deep learning. Nucleic Acids Res. 2023 Oct 11: gkad805.(Cover Story)

Wang S, Girardello M, Zhang W#. Potential and progress of studying mountain biodiversity by means of butterfly genetics and genomics. J. Genet. Genomics 2023 Jun 10:j.jgg.2023.06.001 (Invited review)

Zhang Y*, Zhu Q*, Shao Y, Jiang Y, Ouyang Y, Zhang L#, Zhang W#. Inferring historical introgression with deep learning. Syst. Biol. 2023 Nov 1;72(5):1013-1038. (Cover Story)

Zeng H#*, Zhao D*, Zhang Z, Gao H, Zhang W#. Imperfect ant mimicry contributes to local adaptation in a jumping spider. iScience 2023 May 17:106747. (Reported by Cell Magazine, Science Magazine, NY Times, Phys and ScienceDaily)

Zhang W#, Zhang L, Zhang W. Editorial: The origination of genetic novelties: New genes, new regulations, and new cell types. Front. Genet. 2023 Jan 13:1118926.

Ge D*, Wen Z*, Feijo A*, Lissovsky A*, Zhang W*, Chen J, Yan C, She H, Zhang D, Cheng Y, Lu L, Wu X, Mu D, Zhang Y, Xia L, Qu Y#, Vogler AP#, Yang Q#. Genomic consequences and demographic response to pervasive hybridization over time in climate-sensitive pikas. Mol. Biol. Evol. 2022 Dec 23:msac274.

Wu N, Evans E, van Schooten B, Meléndez-Rosa J, Ortiz Y, Planas Soto-Navarro SM, Van Belleghem SM, Counterman BA, Papa R#, Zhang W#. Widespread gene expression divergence in butterfly sensory tissues plays a fundamental role during reproductive isolation and speciation. Mol. Biol. Evol. 2022 Nov 3;39(11):msac225.(Cover Story)

Wang S*, Teng D*, Li X*, Yang P, Da W, Zhang Y, Zhang Y, Liu G, Zhang X, Wan W, Dong Z, Wang D, Huang S, Jiang Z, Wang Q, Lohman DJ, Wu Y, Zhang L, Jia F, Westerman E, Zhang L, Wang W, Zhang W#. The evolution and diversification of oakleaf butterflies. Cell 2022 Aug 18;185:1-15.(Cover Story, reported by Cell, CNS, Phys and ScienceDaily and recommended by Nature Ecology and Evolution Year in Review)

王姝婷*,滕德群*,张蔚#。以枯叶蛱蝶属为例揭示山地生物多样性演化和遗传机制。遗传 2022 44 (9):731–732.

Wang Y*, Fan Y*, Fan D*, Zhang Y, Zhou X, Zhang R, Wang Y, Sun Y, Zhang W, He Y, Deng XW#, Zhu D#. The Arabidopsis DREAM complex antagonizes WDR5A to modulate histone H3K4me2/3 deposition for a subset of genome repression. Proc. Natl. Acad. Sci. USA 2022 Jul 5;119(27):e2206075119.

He J*, Zhang R*, Yang J*, Chang Z*, Zhu L*, Lu S*, Xie F, Mao J, Dong Z, Liu G, Hu P, Dong Y, Wan W, Zhao R, Xiong T, León-Cortés JL, Mao C, Zhang W, Zhan S, Li J, Chen L#, Wang W#, Li X#. High-quality reference genomes of swallowtail butterflies provide insights into their coloration evolution. Zool. Res. 2022 May 18;43(3):367–379.

Sun T, Song Y, Teng D, Chen Y, Dai J, Ma M, Zhang W, Pastor-Pareja JC#. Atypical laminin spots and pull-generated microtubule-actin projections mediate Drosophila wing adhesion. Cell Rep. 2021 Sep 7;36(10):109667.

Zhang Y*, Teng D*, Lu W*, Liu M*, Zeng H, Cao L, Southcott L, Potdar S, Westerman E, Zhu AJ#, Zhang W#. A widely diverged locus involved in locomotor adaptation in Heliconius butterflies. Sci. Adv. 2021 Aug 4;7(32):eabh2340.(Cover Story)

Teng D, Li F, Zhang W#. Using comprehensive machine-learning models to classify complex morphological characters. Ecol. Evol. 2021 Jun 27;11(15):10421-10431.

Feng Y*, Xu H*, Liu J*, Xie N, Gao L, He Y, Yao Y, Lv F, Zhang Y, Lu J, Zhang W, Li C, Hu X#, Yang Z#, Xiao R. Functional and adaptive significance of promoter mutations that affect divergent myocardial expressions of TRIM72 in primates. Mol. Biol. Evol. 2021 Mar 21;msab083.

Yang J*, Wan W*, Xie M*, Mao J*, Dong Z*, Lu S, He J, Xie F, Liu G, Dai X, Chang Z, Zhao R, Zhang R, Wang S, Zhang Y, Zhang W#, Wang W#, Li X#. Chromosome-level reference genome assembly and gene editing of the dead-leaf butterfly Kallima inachus. Mol. Ecol. Resour. 2020 Jul;20(4):1080-1092.(Cover Story)

Mullen SP#, VanKuren NW, Zhang W, Nallu S, Kristiansen EB, Wuyun Q, Liu K, Hill RI, Briscoe AD, Kronforst MR. Disentangling population history and character evolution among hybridizing lineages. Mol. Biol. Evol. 2020 Jan 13;pii: msaa004.

Zhang W#, Leon-Ricardo BX, van Schooten B, Van Belleghem SM, Counterman BA, McMillan WO, Kronforst MR, Papa R. Comparative transcriptomics provides insights into reticulate and adaptive evolution of a butterfly radiation. Genome Biol. Evol. 2019 Sep 13;11(10):2963-2975.

Chen J*#, Huang Y*, Brachi B*, Yun Q*, Zhang W, Lu W, Li H, Li W, Sun X, Wang G, He J, Zhou Z, Chen K, Ji Y, Shi M, Sun W, Yang Y#, Zhang R#, Abbott RJ#, Sun H#. Genome-wide analysis of Cushion willow provides insights into alpine plant divergence in a biodiversity hotspot. Nat. Commun. 2019 Nov 19;10(1):5230.

Westerman E*, VanKuren N*, Massardo D, Tanger-Trolander A, Zhang W, Hill RI, Perry M, Bayala E, Barr K, Chamberlain N, Douglas TE, Buerkle N, Palmer S, Kronfost MR#. Aristaless controls butterfly wing color variation used in mimicry and mate choice. Curr. Biol. 2018 Nov 5;28(21):3469-3474.e4.

Nallu S, Hill JA, Don K, Sahagun C, Zhang W, Meslin C, Snell-Rood E, Clark NL, Morehouse NI, Bergelson J, Wheat CW, Kronforst MR#. The molecular genetic basis of herbivory between butterflies and their host-plants. Nat. Ecol. Evol. 2018 Sep;2(9):1418-1427. (Reported by Nature Plants)

Zhang W, Westerman E, Nitzany E, Palmer S, Kronforst MR#. Tracing the origin and evolution of supergene mimicry in butterflies. Nat. Commun. 2017 Nov 7;8(1):1269. (Reported by University of Chicago, PBS, and ScienceDaily)

Zhang W#, Dasmahapatra KK, Mallet J, Moreira GR, Kronforst MR#. Genome-wide introgression among distantly related Heliconius butterfly species. Genome Biol. 2016 Feb 27;17(1):25. (Research highlighted by Genome Biology)

Li X*, Fan D*, Zhang W*, Liu G*, Zhang L*, Zhao L, Fang X, Chen L, Dong Y, Chen Y, Ding Y, Zhao R, Feng M, Zhu Y, Feng Y, Jiang X, Zhu D, Xiang H, Feng X, Li S, Wang J, Zhang G, Kronforst MR#, Wang W#. Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies. Nat. Commun. 2015 Sep 10;6:8212.

Zhan S#, Zhang W, Niitepold K, Hsu J, Fernández Haeger J, Zalucki M, Altizer S, De Roode J, Reppert S, Kronforst MR#. The genetics of monarch butterfly migration and warning colouration. Nature. 2014 Oct 16;514(7522):317-21. (Reported by Nature News & Views, Science Magazine, NY Times, National Geographic, Washington Post and NBC News)

Kunte K*#, Zhang W*, Tenger-Trolander A, Palmer D, Martin A, Reed RD, Mullen SP, Kronforst MR#. doublesex is a mimicry supergene. Nature. 2014 Mar 13;507(7491):229-32. (Recommended by Faculty of 1000, reported by Nature News & Views, Nature Magazine, Science Magazine, NY Times, LA Times, Chicago Tribune and University of Chicago and included in An Introduction to Molecular Evolution and Phylogenetics, 2016 Edition and Genetics: From Genes to Genomes (Hartwell), 2017 Edition)

Kronforst MR#, Hansen MEB, Crawford NG, Gallant JR, Zhang W, Kulathinal RJ, Kapan DD, Mullen SP#. Hybridization reveals the evolving genomic architecture of speciation. Cell Rep. 2013 Nov 14;5(3):666-77. (Selected as Cell Report Best of 2013 and reported by Science Magazine, The Economist, LA Times and University of Chicago)

Zhang W, Kunte K, Kronforst MR#. Genome-wide characterization of adaptation and speciation in tiger swallowtail butterflies using de novo transcriptome assemblies. Genome Biol. Evol. 2013;5(6):1233-45. (Cover Story)

Yang C, Zhang W, Ren M, Song L, Li T#, Zhao J#. Whole-genome sequence of Microcystis aeruginosa TAIHU98, a nontoxic bloom-forming strain isolated from Taihu Lake, China. Genome Announ. 2013 Jun 1(3). pii: e00333-13.

Hu Y, Zhang X, Shi Y, Zhou Y, Zhang W, Su XD, Xia B, Zhao J#, Jin C#. Structures of Anabaena calcium-binding Protein CcbP: insights into Ca2+ signaling during heterocyst differentiation. J Biol. Chem. 2011 Apr 286(14): 12381-12388.

Shi Y*, Zhao W*, Zhang W, Ye Z, Zhao J#. Regulation of intracellular free calcium concentration during heterocyst differentiation by HetR and NtcA in Anabaena sp. PCC 7120. Proc. Natl. Acad. Sci. USA 2006 Jul 103(30): 11334-11339.

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