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白凡
邮  箱: fbai(AT)pku.edu.cn
职  称:
研究员
办公室地址: 北京市海淀区颐和园路5号,北京大学,综合科研楼,100871
实验室地址: 北京市海淀区颐和园路5号,北京大学,综合科研楼,100871
个人简历
教育经历
2003.09-2008.09  Doctor of Philosophy major in Biological Physics, University of Oxford
2010.04-2010.05  Visiting Scholar, Virginia Polytechnic Institute and State University
2004.09-2004.12  Visiting Scholar, The University of California at Berkeley
1999.09-2003.06  Bachelor of Science, Peking University, Department of Physics
工作经历
2014.09-present  Assistant Professor, PI
2011.08-2014.08  Assistant Professor, Co-PI with Professor Sunney Xiaoliang Xie.
2009.09-2011.08  JSPS Postdoctoral research fellow, Osaka University
2008.09-2009.09  IRC and EPSRC Postdoctoral research fellow, University of Oxford
荣誉奖励
自然科学基金委 优秀青年基金,2017
Bayer-PKU Young Investigator,2017
第二批青年千人计划学者,2012
科研领域描述
  白凡实验室致力于将先进的单细胞、单分子研究方法,应用于重大医学疾病问题的研究。
  实验室研究方向:
  研究方向一:单细胞基因测序技术应用于癌症病人外周血循环肿瘤细胞研究,深入探索癌症转移的分子生物学机制及通过循环肿瘤细胞测序进行无创癌症诊断、预后判断、疗效评价的临床方法。
  研究方向二:大样本基因测序研究癌症发生、转移机制。针对明确的临床问题,采用基因测序手段研究中国人群高发癌症的基因突变特征,发掘引起癌症表型转化、转移的关键驱动事件。
  研究方向三:综合使用基因测序、荧光成像手段研究细菌行为、致病性,抗生素杀菌原理和细菌抗药、耐药的分子机制。
代表性论文
单细胞测序及癌症基因组学方向:
<2017>
15.Li Y, Wu S, Bai F*, Molecular characterization of circulating tumor cells—from bench to bedside, Seminars in Cell & Developmental Biology, (*corresponding author)(in press)
14.Chen X#, Yan S#, Liu Y#, Zhong Q#, Chen Z#, Jin S#, Xia T, Li R, Zhou A, Su Z, Huang Y, Huang Q, Huang L, Zhang X, Zhao Y, Yun J, Wu Q, Lin D, Bai F*, Zeng M*, Genomic comparison of esophageal squamous cell carcinoma and its precursor lesions by multi-region whole exome sequencing, Nature Communications, 8 (2017), pp.524 doi: 10.1038/s41467-017-00650-0(*corresponding author)
13.Li J#, Liu K#, Chen H#, Li R, Drechsler M, Bai F*, Huang J*, Tang B*, Yan Y*, Functional build-in template directed siliceous fluorescent supramolecular vesicles as diagnostics, ACS Applied Materials & Interfaces (2017)(*corresponding author)(in press)
12.Fang Y#, Su Z#, Xie J#, Xue R, Ma Q, Lu X, Wang X, Wen C, Shi M, Tang X, Chen H, Zhan Q, Li H, Deng X, Peng C, Bai F*, Shen B*, Genomic signatures of adenosquamous carcinoma of pancreas in Chinese population,Journal of Pathology (2017)(*corresponding author)(in press)
Highlighted by Invited Commentaries "Recent advances in genomic profiling of adenosquamous carcinoma of the pancreas"
11.Gao Y#, Ni X#, Guo H#, Su Z#, Ba Y#, Tong Z, Guo Z, Yao X, Chen X, Yin J, Yan Z, Guo L, Liu Y, Bai F*, Xie S*, Zhang N*, Single-cell sequencing deciphers a convergent evolution of copy number alterations from primary to circulating tumour cells, Genome Research 27 (2017), pp.1312-1322(*corresponding author)
10. Du Y#, Li R#, Chen Z#, Wang X, Xu T*, Bai F*, Mutagenic factors and complex clonal relationship of multifocal urothelial cell carcinoma, European Urology 71 (2017), pp.841–843 (*corresponding author)

<2016>
9. Xue R, Li R, Zhang N*, Bai F*, Understanding intra-tumor heterogeneity and tumor evolution to facilitate hepatocellular carcinoma therapy, Translational Cancer Research 3 (2016), pp. S604-S605 (*corresponding author)
8. Xue R#, Li R#, Guo H#, Guo L#, Su Z, Ni X, Qi L, Zhang T, Li Q, Zhang Z, Xie XS, Bai F*, Zhang N* , Variable extent of intra-tumor heterogeneity revealed by genomic sequencing of multiple lesions in patients with hepatocellular carcinoma , Gastroenterology 150 (2016), pp. 998-1008 (*corresponding author)
Highlighted by Editorial "Heterogeneity among liver cancer-a hurdle to optimizing therapy" of the same issue,
Highlighted by "The genetic heterogeneity of hepatocellular carcinoma and the implications for personalised medicine" Translational Cancer Research 5,(Suppl 1):S1-S4 (2016).

<2015>
7. Chen XX, Bai F*, Single-cell analyses of circulating tumor cells, Cancer Biology & Medicine 12 (2015), pp. 184-192 (*corresponding author)

<2014>
6. Zhang J, Tian X, Zhang H, Teng Y, Li R, Bai F, Elankumaran S, Xing J , TGF-β–induced epithelial-to-mesenchymal transition proceeds through stepwise activation of multiple feedback loops, Science Signaling 7 (2014), ra91
5. Xue R, Li R, Bai F* , Single cell sequencing: technique, application and future development , Science Bulletin (2014), doi: 10.1007/ s11434-014-0634-6 (*corresponding author)

<2013>
4. He Y, Tsutsui M, Scheicher RH, Bai F, Taniguchi M, Kawai T , Thermophoretic manipulation of DNA translocation through nanopores , ACS Nano , 2013 , 7: 538–546  
3. Ni X#, Zhuo M#, Su Z#, Duan J#, Gao Y#, Wang Z#, Zong C#, Bai H, Chapman A, Zhao J, Xu L, An T, Ma Q, Wang Y, Wu M, Sun Y, Wang S, Li Z, Yang X, Yong J, Su X, Lu Y, Bai F*, Xie XS*, Wang J* , Reproducible copy number variation patterns among single circulating tumor cells of lung cancer patients , Proceedings of the National Academy of Sciences USA , 2013 , 110: 21083-21088 (*corresponding author)
Highlighted by "Singled out for sequencing" Nature Methods 11, 13–17 (2014)

<2012>
2. Hu X, Yuan J, Shi Y, Lu J, Liu B, Li Z, Chen Z, Mu D, Zhang H, Li N, Yue Z, Bai F, Li H, Fan W , pIRS: Profile based illumina pair-end reads simulator , Bioinformatics , 2012 , 28: 1533-1535  
1. Lu S#, Zong C#, Fan W#, Yang M#, Li J, Chapman A, Zhu P, Hu X, Xu L, Yan L, Bai F, Qiao J, Tang F, Li R, Xie XS , Probing meiotic recombination and aneuploidy of single sperm cells by whole genome sequencing , Science , 2012 , 338: 1627-1630  

细菌生理学、致病性及抗生素耐药:
<2017>
22. Jin X, Guo X*, Xu D, Zhao Y, Bai F*, Single-cell real-time visualization and quantification of perylene bioaccumulation in microorganisms, Environmental Science & Technology 51 (2017),pp. 6211–6219(*corresponding author)
21. Chen M#, Zhao Z#, Yang J#, Peng K, Baker M, Bai F*, Lo C*, Length-dependent flagellar growth of Vibrio alginolyticus revealed by real time fluorescent imaging, eLIFE (2017), DOI: http://dx.doi.org/10.7554/eLife.22140(*corresponding author)
20. Pu Y, Ke Y*, Bai F*, Active efflux in dormant bacterial cells – new insights into antibiotic persistence, Drug Resistance Updates 30 (2017), pp.7-14 (*corresponding author)

<2016>
19. Buda R#, Liu Y#, Yang J#, Hegde S#, Stevenson K, Bai F* and Pilizota T*, Dynamics of Escherichia coli`s passive response to a sudden decreases in external osmolarity, Proceedings of the National Academy of Sciences USA 113 (2016), pp. E5838-E5846 (*corresponding author)
18. Zhu J, Li H, Feng L, Yang M, Yang R, Yang L, Li L, Li R, Liu M, Hou S, Ke Y*, Li W*, Bai F*, Severe chronic osteomyelitis caused by Morganella morganii with high population diversity, International Journal of Infectious Diseases 50 (2016), pp. 44-47 (*corresponding author)
17. Pu Y#, Zhao Z#, Li Y#, Zou J, Ma Q, Zhao Y, Ke Y, Zhu Y, Chen H, Baker A.B. M, Ge H, Sun Y, Xie XS*, Bai F* , Enhanced efflux activity facilitates drug tolerance in dormant bacterial cells , Molecular Cell 62 (2016), pp. 284-294 (*corresponding author)
Highlighted by "Microbiology:Pumping persisters" Nature 534, 41–42 (2016)
Highlighted by "Persisters are under the pump" Nature Reviews Microbiology 14, 332–333 (2016)
16. Ma Q, Sowa Y, Baker M*, Bai F* , Conformational spread in the flagellar motor switch in response to CheY-P regulation and motor structural alterations , Biophysical Journal 110 (2016), pp. 1411-1420 (*corresponding author)

<2015>
15. Xue R, Ma Q, Baker M*, Bai F*, A delicate nanoscale motor made by nature-the bacterial flagellar motor, Advanced Science 2 (2015)(*corresponding author)
14. Guo X*, Jin X, Lv X, Pu Y, Bai F* ,Real time visualization of perylene nano-clusters (PNCs) in water and their partitioning to graphene surface and macrophage cells , Environmental Science & Technology , (2015), doi: 10.1021/acs.est.5b01880 (*corresponding author)

<2014>
13. Bai F, Morimoto Y, Yoshimura S, Hara N, Kami-ike N, Namba K, Minamino T., Assembly dynamics and the roles of FliI ATPase of the bacterial flagellar type III export apparatus , Scientific Reports 4 (2014), Article number: 6528
12. Liu Y, Yang J, Zhao Z, Pu Y*, Bai F* , Bacterial persistence , Science China Chemistry , 57 (2014), pp. 1625-1633 (*corresponding author)
11. Morimoto Y, Ito M, Hiraoka K, Che YS, Bai F, Kami-ike N, Namba K, Minamino T , Assembly and stoichiometry of FliF and FlhA in Salmonella flagellar basal body , Molecular Microbiology , 2014 , 91: 1214-1226  

<2013>
10. Bai F, Che YS, Kami-ike N, Ma Q, Minamino T, Sowa Y, Namba K , Populational heterogeneity vs. temporal fluctuation in Escherichia coli flagellar motor switching , Biophysical Journal , 2013 , 105, 2123-2129  

<2012>
9. Bai F, Minamino T, Wu Z, Namba K, Xing J , Coupling between switching regulation and torque generation in bacterial flagellar motor , Physical Review Letters , 2012 , 108: 178105  
8. Ma Q, Nicolau D, Berry R, Maini P. Bai F. , Conformational spread in the flagellar motor switch: a model study , PLoS Computational Biology , 2012 , 8: e1002523  

<2011>
7. Mora T#, Bai F#, Che Y, Minamino T, Namba K, Wingreen N., Non-genetic individuality in Escherichia coli motor switching , Physical Biology (Communication) , 2011, 8: 024001 (#equal contribution)
6. Little M, Steel B, Bai F, Sowa Y, Bilyard T, Mueller D, Berry R, Jones N , Steps and bumps: precision extraction of discrete states of molecular machines using physically-based, high-throughput time series analysis , Biophysical Journal , 2011 , 101: 477-485.

<2010>
5. Bai F, Branch R, Nicolau D, Pilizota T, Steel, B, Maini P, Berry R , Conformational spread as a mechanism for cooperativity in the bacterial flagellar switch , Science , 2010 , 327: 685-689
Highlighted by Perspective "An Ensemble View of Allostery" in the same issue

<2009>
4. Bai F, Lo C, Berry R, Xing J , Model studies on the dynamics of bacterial flagellar motor , Biophysical Journal , 2009 , 96: 3154-3167

<2007>
3. Pilizota T, Bilyard T, Bai F, Futai M, Hosokawa H, Berry R , A programmable optical angle clamp for rotary molecular motors , Biophysical Journal , 2007 , 93: 264-275

<2006>
2. Leake MC, Chandler JH, Wadhams GH, Bai F, Berry RM, Armitage JP , Stoichiometry and turnover in single, functioning membrane protein complexes , Nature , 2006 , 443: 355-358  
1. Xing J, Bai F, Berry R, Oster G. , Torque-speed relationship of the bacterial flagellar motor , Proceedings of the National Academy of Sciences USA , 2006 , 103: 1260-1265
执教课程
秋季学期
    整合科学实验 I II III
    生物成像导论

春季学期
    细胞中的物理
实验室简介
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