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周卓
邮  箱: zhouzhuo(AT)pku.edu.cn
职  称:
副研究员
实验室地址: 北京市海淀区颐和园路5号,北京大学,金光生命科学大楼,100871
个人简历
教育经历
2008-2012,中国医学科学院病原生物学研究所,博士后
2002-2007,南开大学,博士
1998-2002,天津商学院,学士
工作经历
2017-至今,副研究员,北京大学生命科学学院
2015-2017,副研究员/硕士生导师,中国医学科学院病原生物学研究所/北京协和医学院
2015-2016,访问学者,Icahn School of Medicine at Mount Sinai, New York
2012-2015,助理研究员,中国医学科学院病原生物学研究所
代表性论文
13. Jia, X., Zhou, H., Wu, C., Wu, Q., Ma, S., Wei, C., Cao, Y., Song, j., Zhong, H., Zhou, Z#., Wang J#. (2017). The ubiquitin ligase RNF125 targets innate immune adaptor protein TRIM14 for ubiquitination and degradation. J Immunol 1601322 (#co-corresponding author)

12. Lei, X., Xiao, X., Zhang, Z., Ma, Y., Qi, J., Wu, C., Xiao, Y., Zhou, Z., He, B., Wang, J. (2017). The Golgi protein ACBD3 facilitates Enterovirus 71 replication by interacting with 3A. Sci Rep 17, 7:44592.

11. Xiang, Z., Liu, L., Lei, X., Zhou, Z., He, B., and Wang, J. (2016). 3C Protease of Enterovirus D68 Inhibits Cellular Defense Mediated by Interferon Regulatory Factor 7. J Virol 90, 1613-1621.

10. Xiang, Z., Li, L., Lei, X., Zhou, H., Zhou, Z., He, B., and Wang, J. (2014). Enterovirus 68 3C protease cleaves TRIF to attenuate antiviral responses mediated by Toll-like receptor 3. J Virol 88, 6650-6659.

9. Zhou, Z*., Jia, X*., Xue, Q*., Dou, Z., Ma, Y., Zhao, Z., Jiang, Z., He, B., Jin, Q., and Wang, J. (2014). TRIM14 is a mitochondrial adaptor that facilitates retinoic acid-inducible gene-I-like receptor-mediated innate immune response. Proc Natl Acad Sci U S A 111, E245-E254. (*co-first author)

8. Zhou, Z*., Cao*, M., Guo, Y*., Zhao, L., Wang, J., Jia, X., Li, J., Wang, C., Gabriel, G., and Xue, Q., et al. (2014). Fragile X mental retardation protein stimulates ribonucleoprotein assembly of influenza A virus. Nat Commun 5, 3259. (*co-first author) (Featured Article)

7. Zhou, Z., Gao, X., Wang, Y., Zhou, H., Wu, C., Paranhos-Baccala, G., Vernet, G., Guo, L., and Wang, J. (2014). Conserved B-cell epitopes among human bocavirus species indicate potential diagnostic targets. PLoS One 9, e86960.

6. Xue, Q., Zhou, Z., Lei, X., Liu, X., He, B., Wang, J., and Hung, T. (2012). TRIM38 negatively regulates TLR3-mediated IFN-beta signaling by targeting TRIF for degradation. PLoS One 7, e46825.

5. Zhou, Z., Xue, Q., Wan, Y., Yang, Y., Wang, J., and Hung, T. (2011). Lysosome-associated membrane glycoprotein 3 is involved in influenza A virus replication in human lung epithelial (A549) cells. Virol J 8, 384.

4. Liu, X., Lei, X., Zhou, Z., Sun, Z., Xue, Q., Wang, J., and Hung, T. (2011). Enterovirus 71 induces degradation of TRIM38, a potential E3 ubiquitin ligase. Virol J 8, 61.

3. Qin, L., Ren, L., Zhou, Z., Lei, X., Chen, L., Xue, Q., Liu, X., Wang, J., and Hung, T. (2011). Rotavirus nonstructural protein 1 antagonizes innate immune response by interacting with retinoic acid inducible gene I. Virol J 8, 526.

2. Wan, Y., Zhou, Z., Yang, Y., Wang, J., and Hung, T. (2010). Application of an In-Cell Western assay for measurement of influenza A virus replication. J Virol Methods 169, 359-364.

1. Zhou, Z., Yin, J., Dou, Z., Tang, J., Zhang, C., and Cao, Y. (2007). The calponin homology domain of Vav1 associates with calmodulin and is prerequisite to T cell antigen receptor-induced calcium release in Jurkat T lymphocytes. J Biol Chem 282, 23737-23744.
实验室简介

致力于发展基因组编辑技术,关注高通量功能基因组学;在此基础上研究癌症、感染等重大疾病的分子机制,为发展高效治疗手段提供新的药物靶点和思路。近期成果包括:首次发现艰难梭菌毒素受体;完成对TALE蛋白识别非修饰及修饰DNA碱基的完全解码;开发了基于CRISPR/Cas9系统的基因敲除文库及高通量功能性筛选平台;完成多种病毒侵染人源宿主重要靶位点的筛选和功能鉴定;建立了基因组大片段删除技术用于高通量筛选研究长片段非编码RNAlncRNA)。

实验室电话: 10-62756762
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