__尚永丰 博士; 博士生导师; 医学部生物化学与分子生物学系教授
美国宾夕法尼亚州立大学 博士；
美国哈佛大学医学院 博士后；
2002年国家杰出青年科学基金获得者；
教育部“长江学者奖励计划”特聘教授。
现担任：
跨院系“北京大学蛋白质科学中心” 副主任；
北京大学基础医学院生化与分子生物学系 主任；
中国生物化学与分子生物学会 常务理事；
《中国生物化学与分子生物学报》 副主编。
主要研究方向：
（1）新基因的克隆与功能分析；
（2）核受体介导的基因转录的调控；
（3）性激素相关肿瘤病理发生的分子生物学基础。

Professor Yongfeng Shang

Education and Employment: PhD: The Pennsylvania State University;Postdoctoral training: Dana-Farber Cancer Institute, Harvard Medical School
Current Positions: “Cheung Kong Scholar” Professor and Chair, Department of Biochemistry and Molecular Biology, Peking University Health Science Center.
Research Interests: Molecular cloning and functional analysis of human novel genes; nuclear receptor-mediated gene transcription; molecular basis for sex hormone-related carcinogenesis.

代表性论文(Selected Publications)：
1. Huijian Wu, Yupeng Chen, Jing Liang, Bin Shi, Ge Wu, Ying Zhang, Dan Wang, Ruifang Li, Xia Yi, Hua Zhang, Luyang Sun, and Yongfeng Shang (2005). Hypomethylation-linked activation of PAX2 mediates tamoxifen-stimulated endometrial carcinogenesis. Nature 438, 981-987
2. Yongfeng Shang?. Pathogenic mechanisms of oestrogen and SERMs in endometrial cancer. Nature Reviews Cancer (invited article)
3. Hua Zhang, Xia Yi, Xiaojing Sun, Na Yin, Bin Shi, Huijian Wu, Dan Wang, Ge Wu, and Yongfeng Shang? (2004). Differential Gene Regulation by the SRC Family of Coactivators. Genes and Development 18: 1753-1765.
4. Na Yin, Dan Wang, Hua Zhang, Xia Yi, Xiaojing Sun, Bin Shi, Huijian Wu, Ge Wu, Xinjuan Wang, and Yongfeng Shang? (2004). Molecular Mechanisms Involved in the Growth Stimulation of Breast Cancer Cells by Leptin. Cancer Research 64: 5870-5875
5. Xiaojing Sun, Hua Zhang, Dan Wang, Yan Shen?, and Yongfeng Shang? (2004). DLP, A Novel Dim1 Family Protein Implicated in Pre-mRNA Splicing and Cell Cycle Progression. Journal of Biological Chemistry 279: 32839-32847
6. Ma Han, Yongfeng Shang, DY Lee, and Michael Stallcup (2003). Study of nuclear receptor-induced transcription complex assembly and histone modification by chromatin immunoprecipitation assays. Methods in Enzymology 364: 284-296
7. Zebin Mao, Song Shan, Yunyan Zhu, Xia Yi, Hua Zhang, Yongfeng Shang, and Tanjun Tong (2003). Transcriptional Regulation of A33 Antigen Expression by Gut-enriched Krüppel-like Factor (GKLF). Oncogene 22: 4434-4443
8. Yongfeng Shang and Myles Brown (2002). Molecular determinants for the tissue specificity of SERMs. Science 295: 2465-2468
9. Yongfeng Shang, Molly Myers and Myles Brown (2002). The formation of androgen receptor transcription complex. Molecular Cell 9: 601-610
10. Maricarmen D. Planas-Silva, Yongfeng Shang, Joana Liu Donaher, Myles Brown, and Robert A. Weinberg (2001).? AIB1 enhances estrogen- dependent induction of cyclin D1 expression. Cancer Research 61: 3858-3862
11. Yongfeng Shang, Xiao Hu, James Direnzo, Mitch Lazar, and Myles Brown (2000). Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription. Cell 103: 843-852
12.James DiRenzo, Yongfeng Shang, Michael Phelan, Said Sif, Molly Yancisin, Robert Kingston, and Myles Brown (2000). BRG-1 is recruited to estrogen-responsive promoters and cooperates with factors involved in histone acetylation. Molecular and Cellular Biology 20: 7541-7549
13. Yongfeng Shang, Craig R. Baumrucker, and Michael H. Green (1999). Induction and activation of signal transducer and activator of transcription (STAT) 1 by all-trans-retinoic acid in breast cancer cells is mediated by RAR? signaling pathways. Oncogene 18: 6725-6732
14. Yongfeng Shang, Craig R. Baumrucker, and Michael H. Green (1999). Signal relay by RAR and RAR in retinoic acid-induced IGFBP3 expression in breast cancer cells. Journal of Biological Chemistry 274: 18005-18010
15. Yongfeng Shang, Craig R. Baumrucker, and Michael H. Green (1998). c-Myc is a major mediator of the synergistic growth inhibitory effects of retinoic acid and interferon in breast cancer cells. Journal of Biological Chemistry 273: 30608-30613

联系方式(Contact Information)：
电话(Tel.)：010-8280-5118； 传真(Fax)：010-8280-1355
电子信箱(e-mail)：jason@bjmu.edu.cn
通信地址(address)：北京大学医学部基础医学院生物化学与分子生物学系，北京 100083