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邓宏魁教授(长江特聘教授)
Professor Hongkui Deng (Changjiang Professor)

1980-1984年
1984-1987年
1990-1995年
  武汉大学,学士
上海第二医科大学,硕士
美国加州大学洛杉矶分校(UCLA),博士
 
1980-1984
1984-1987
1990-1995
  B.S, Wuhan University
M.S, Shanghai Second Medical University
Ph.D, University of California, Los Angeles

研究方向:
1. 干细胞自我更新及定向分化的分子调控
2. 研究宿主蛋白与艾滋病病毒和肝炎病毒相互作用的分子机制
3. 运用化学遗传学的手段,寻找靶点,筛选针对肿瘤干细胞的抗癌药物及抗病毒的新药
4. 通过遗传修饰的手段建立疾病动物模型
 
Research Fields:
1. Stem cell biology
2. Virus-host interaction
3. Chemical genomics
4. Animal models for disease research

Recent Publications:

1. Directed differentiation of human embryonic stem cells into functional hepatic cells. Cai J, Zhao Y, Ye F, Liu Y, Song Zhi, Qin H, Meng S, Chen Y, Zhou R, Song X, Guo Y, Ding M and Deng H. Hepatology. 2007. (in press).

2. A Critical Role for MEK/ERK Signaling in Regulating Human Embryonic Stem Cell Self-renewal. Li J, Wang C, Wang G, Zhao Y, Zhang H, Song Z, Ding M and Deng H. Differentiation. 2007 Feb 5; [Epub ahead of print].

3. Developmental stage related patterns of codon usage and genomic GC content: searching for evolutionary fingerprint by models of stem cell differentiation. Ren L, Gao G, Zhao D, Ding M, Luo J and Deng H. Genome Biol. 2007 Mar 12;8(3):R35 [Epub ahead of print]

4. Regulation of apoptosis and differentiation by p53 in human embryonic stem cells. Qin H, Yu T, Qing T, Liu Y, Zhao Y, Cai J, Li J, Song Z, Qu X, Zhou P, Wu J, Ding M and Deng H. J. Biol. Chem. 2007, Feb 23; 282(8):5842-52.

5. Live offspring produced by mouse oocytes derived from premeiotic fetal germ cells. Shen W, Qing T, Bai Z, Cheng J, Shi Y, Zhang D, Ding M and Deng H. Biology of Reproduction. 2006, 75(4):615-23.

6. Induction of neutralizing antibody against human immunodeficiency virus type 1 (HIV-1) by immunization with gp41 membrane-proximal external region (MPER) fused with porcine endogenous retrovirus (PERV) p15E fragment. Lou M, Yuan F, Liu Y, Jiang S, Song X, Jiang P, Yin X, Ding M, Deng H. Vaccine. 2006, 24(4):435-42

7. Inducing embryonic stem cells to differentiate into pancreatic beta cells by a novel three-step approach with activin A and all-trans retinoic acid. Shi Y, Hou L, Tang F, Jiang W, Wang P, Ding M, Deng H. Stem Cells. 2005, 23(5):656-62.

8. The proteasomal inhibitor MG132 increases the efficiency of mouse embryo production after cloning by electrofusion. Yu Y, Yong J, Li X, Qing T, Qin H, Xiong X, You J, Ding M, Deng H. Reproduction, 2005, 130(4):553-8.

9. Identification of two critical amino acid residues of the severe acute respiratory syndrome coronavirus spike protein for its variation in zoonotic tropism transition via a double substitution strategy. Qu X, Hao P, Song X, Jiang S, Liu Y, Wang P, Rao X, Song H, Wang S, Zuo Y, Zheng A, Luo M, Wang H, Deng F, Hu Z, Ding M, Zhao G, Deng H. J Biol Chem. 2005; 280(33):29588-95.

10. Small molecules blocking the entry of severe acute respiratory syndrome coronavirus into host cells. Yi L, Li Z, Yuan K, Qu X, Chen J, Wang G, Zhang H, Luo H, Zhu L, Jiang P, Chen L, Shen Y, Luo M, Zuo G, Hu J, Duan D, Nie Y, Shi X, Wang W, Han Y, Li T, Liu Y, Ding M, Deng H, Xu X. J Virol. 2004, 78(20):11334-9.

11. Identification of an antigenic determinant on the S2 domain of the severe acute respiratory syndrome coronavirus spike glycoprotein capable of inducing neutralizing antibodies. Zhang H, Wang G, Li J, Nie Y, Shi X, Lian G, Wang W, Yin X, Zhao Y, Qu X, Ding M, Deng H. J Virol. 2004, 78(13):6938-45.

12. Introduction of an endopeptidase cleavage motif into a determinant flanking region of HEL results in enhanced T cell determinant display. Schneider, S.C., Ohmen,J., Fosdick, L., Gladstone, B., Guo, J., Ametani, A., Sercarz, E.E., Deng, H. J. Immunol. 2000. 165:20-26.

13. Expression cloning of novel coreceptors utilized by the simion and human immunodeficency viruses. Deng, H., Unutmaz, D., Kewalramani, V., and Littman, D.R. Nature. 1997. 388:296-300

14. Identification of a major co-receptor for primary isolates HIV-1. Deng, H., Liu, R., Ellmeier, W., Choe, S., Untmaz, D., Burkhart, M., Marazio, P.D., Marmon, S., Sutton, R.E., Hill, C.M., Davis, C.B., Peiper, S.C., Schall, T.J., Littman, D.R. and Landau, N.R. Nature. 1996. 381:661-666.

 



Fax: 010-62756474 Phone: 010-62756954
E-mail: Hongkui_deng@pku.edu.cn

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