教育经历:
2001-2006, 理学博士, 分子遗传学, 杜克大学
1996-2000, 理学学士, 细胞遗传, 北京大学
荣誉奖励:
2021, 第三届神经细胞生物学青年前沿论坛特邀报告人奖
2019, 入选 Journal of Cell Biology 杂志青年顾问委员会
2016, 北京大学生命科学学院最受学生喜爱教师奖/沈同尊师奖
2015, 北京大学青年教师教学基本功比赛二等奖
2015, 北京大学教学优秀奖
2006, 医学院院长博士后奖学金, 斯坦福大学, 美国
2005, 基石研讨会(Keystone Symposium) 摘要奖, 美国
2002-2006, 霍华德·休斯医学研究所(HHMI) 博士奖学金, 美国工作经历:
2020-今,长聘副教授/研究员, 北京大学生命科学学院
2019-今,研究员,北大-清华生命科学联合中心 (CLS)
2013-2019,助理教授/研究员,北京大学生命科学学院
2013-2018,青年学者,北大-清华生命科学联合中心 (CLS)
2011-2012,Research associate,病理学系, 斯坦福大学
2006-2011,博士后,病理学系,斯坦福大学学术任职:
2020-今,中国神经学会发育与再生分会委员
2016-今,中国细胞生物学学会青年工作委员会委员
杂志任职:
2019-今,Journal of Cell Biology 杂志青年顾问委员会委员 (Early Career Advisory Board member)评审任职:
杂志评审:Developmental Cell; Science Advances; Nature Communications; Elife; Journal of Cell Biology; Cell Reports; PLOS Genetics; Development; JGG会议发言与组织:
会议组织:EMBO Workshop - Molecular and Developmental Biology of Drosophila (2022; 2024; 2026)杂志编辑:
PLOS Genetics 杂志,编辑 (Associate Editor) /
Journal of Genetics and Genomics 杂志,编辑 (Editor) /
Developmental Biology 杂志,特邀编辑 (Guest Editor)
执教课程:
本科生,遗传学,主讲,北京大学,春季学期
本科生,生命科学前沿评论及分析,主讲,北京大学,春/秋季学期
研究生, CLS项目细胞生物学,讲课,北京大学,秋季学期
研究生, CLS项目遗传学,讲课,北京大学,秋季学期
研究生, PTN项目发育生物学,讲课,北京大学,春季学期
课题组致力于探索神经干细胞谱系内细胞命运及时、精确决定的分子调控机理,以及这些关键决策事件发生错误如何导致神经发育异常和疾病发生。时间和空间信号如何有机耦合决定细胞命运并确保神经元的多样性一直是神经发育领域重要的未解之谜。快速分裂的果蝇神经干细胞谱系为研究干细胞命运决定的时程调控提供了独特而理想的模型。课题组通过将完整脑神经干细胞谱系延时成像技术与强大的果蝇及小鼠遗传学、细胞生物学、生物化学、液-液相分离及基因组学等跨学科手段相结合,揭示时空信号调控神经干细胞谱系内关键细胞命运决策事件的重要分子机理。
实验室更多信息请访问: http://yansonglab.org
*corresponding author; #contribute equally
1. Song Y.* (2022) It takes two to tango: The dance of cell fate specification. Developmental Biology, 490:125. (Editorial for a Special Issue on Transcriptional and epigenetic control of cell fate specification)
2. Liu X.#, Shen J.#, Xie L., Wei Z., Wong C., Li Y., Zheng X., Li P. and Song Y.* (2020) Mitotic implantation of a transcription factor via phase separation drives terminal neuronal differentiation. Developmental Cell, 52(3), 277-293; doi.org/10.1016/j.devcel.2019.11.019 [Featured Article].
Highlighted in Developmental Cell: Bonnay F. and Knoblich J.A.* (2020) Prospero Phase-Separating the Way to Neuronal Differentiation. Developmental Cell, 52(3), 251-252.
3. Li B.#, Wong C.#, Gao S.M., Zhang R., Sun R., Li Y. and Song Y.* (2018) The retromer complex safeguards against neural progenitor-derived tumorigenesis by regulating Notch receptor trafficking. Elife 2018;7;e38181 DOI: 10.7554/eLife.38181
Press release by Elife: https://elifesciences.org/for-the-press/3d24b574/body-s-own-bomb-squad-can-help-protect-against-brain-tumors
4. Xu K., Liu X., Wang Y., Wong C. and Song Y.* (2018) Temporospatial induction of homeodomain gene cut dictates natural lineage reprogramming. Elife 2018;7:e33934 DOI: 10.7554/eLife.33934
5. Jing M., Zhang P., Wang G., Jiang H., Mesik L., Feng J., Wang S., Looby J., Guagliardo N.A., Langma L.W., Lu J., Zuo Y., Talmage D.A., Role L.W., Barrett P.Q., Zhang L.I., Luo M., Song Y., Zhu J.* and Li Y.* (2018). A genetically-encoded fluorescent acetylcholine indicator for in vitro and in vivo studies. Nature Biotechnology 36:726–737
6. Liu K., Shen D., Shen J., Gao S.M., Li B., Wong C., Feng W. and Song Y.* (2017) The super elongation complex drives neural stem cell fate commitment. Developmental Cell, 40(6), 537-551 [Cover article].
Highlighted in Developmental Cell: Rossi A.M. and Desplan C.* (2017) Asymmetric Notch Amplification to Secure Stem Cell Identity. Developmental Cell, 40(6), 513-514.
Recommended by F1000Prime: https://f1000.com/prime/727458399
7. Liu K., Xu K. and Song Y.* (2019) Faster, Higher, Stronger: Timely and robust cell fate/identity commitment in stem cell lineages. Open Biology, 9: 180243. [Invited review]
8. Wu Y.C., Lee K.S., Song Y., Gehrke S., Lu B.* (2017) The bantam microRNA acts through Numb to exert cell growth control and feedback regulation of Notch in tumor-forming stem cells in the Drosophila brain. PLoS Genetics, 13(5):e1006785.
9. Lee K.S.#, Wu Z.#, Song Y., Mitra S.S., Feroze A.H., Cheshier S.H., Lu B.* (2013) Roles of PINK1, mTORC2, and mitochondria in preserving brain tumor-forming stem cells in a noncanonical Notch signaling pathway. Genes & Development, 27(24):2642-7 [Cover article]
10. Song Y. and Lu B.* (2012) Interaction of Notch signaling modulator Numb with α-Adaptin regulates endocytosis of Notch pathway components and cell fate determination of neural stem cells. Journal of Biological Chemistry, 287(21):17716-28.
11. Ouyang Y.#, Song Y.# and Lu B.* (2011) dp53 restrains ectopic neural stem cell formation in the Drosophila brain in a non-apoptotic mechanism involving Archipelago and Cyclin E. PLoS ONE, 6(11):e28098 (# contribute equally).
12. Song Y. and Lu B.* (2011) Regulation of cell growth by Notch signaling and its differential requirement in normal vs. tumor-forming stem cells in Drosophila. Genes & Development, 25(24):2644-2658.
13. Yu L., Song Y. and Wharton R.P.* (2010) E(nos)/CG4699 required for nanos function in the female germ line of Drosophila. Genesis, 48(3):161-70. [Cover article]
14. Song Y., Fee L., Lee T. and Wharton R.P.* (2007) The molecular chaperone Hsp90 is required for mRNA localization in Drosophila melanogaster embryos. Genetics, 176(4):2213-22.