生命学院学术报告

Title：Structure and molecular mechanism of the anaphase-promoting complex

演讲人：Leifu Chang, Ph.D.

Investigator Scientist

MRC Laboratory of Molecular Biology, Cambridge, UK.

时间：2016年12月6日下午13:00-14:00

地点：新生物楼411

Abstract:

The anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase that controls the cell cycle progression by regulating ubiquitin-dependent proteolysis of specific cell-cycle proteins. Human APC/C is composed of 19 subunits from 14 distinct proteins, and its activity is dependent on coactivators (Cdc20 and Cdh1). During the cell cycle, the activity of APC/C is strictly regulated to ensure the correct order and timing of cell-cycle transitions. Using cryo-electron microscopy (cryo-EM), we determined atomic structures of human APC/C in multiple functional states. I will discuss the molecular mechanisms of APC/C regulation by coactivators, early mitotic inhibitor 1 (Emi1), mitotic phosphorylation and spindle assembly checkpoint (SAC).

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