Dr. Shi-Qiang Wang received his B.S. and Ph.D. degrees from College of Life Sciences, Peking University, China in 1990 and 1998, respectively. In 2003, he completed postdoctoral research in National Institute on Aging, NIH, USA, and retuned to Peking University. In 2005, he was honored as a Cheung Kong Scholar Professor by the Ministry of Education. Dr. Wang’s studies have been focused on the molecular basis of intracellular Ca2+ signaling. He combines state-of-the-art confocal imaging, single-channel patch clamping, single-molecule tracing with molecular cell biology techniques to dissect the molecular mechanisms underlying the generation, amplification and termination of intracellular Ca2+ dynamics, aiming to answer important questions about the function, development and dysfunction of the heart. Many of his work were published in high profile journals, including Nature, PLoS Biology, PNAS and Circulation Research. He gained a number of nationally and internationally-recognized awards and prizes, such as the Chang Hsi-chun Young Investigator Prize by Chinese Association for Physiological Sciences (1997), the Richard J. Bing Young Investigator Award by International Society for Heart Research (2001), the Katz Basic Science Research Prize by American Heart Association (2002), the National Awards for Outstanding Young Scientist by the National Natural Science Fundation of China (2004), the Cheung Kong Scholar Professor by China Ministry of Education (2006), the National Awardee of the “Bai Qian Wan” Scholar Program by China Ministry of Human Resources and Social Security (2009), the Government Special Allowance by the State Council of China (2011), Leader Scientist of Sci-Tech Innovation, National 10 Thousand Talents Project (2014), National Outstanding Scientist by Chinese Association of Science and Technology (2016), and the Natural Science Prize (2017).
1999.1 - 2003.11, Postdoctoral fellow and Research Associate, National Institute on Aging, NIH
1992.9 - 1998.7, Ph.D., Physiology, Peking University
1986.9 - 1990.7, B.S., Physiology & Biophysics, Peking University
2003.8 - present, Professor, College of Life Sciences, Peking University
1999.7 - 2003.7, Associate Professor, College of Life Sciences, Peking University
1994.7 - 1999.6, Lecturer, College of Life Sciences, Peking University
1990.8 - 1994.6, Assistant Lecturer, Department of Biology, Peking University
Molecular mechanism of calcium signaling
Ca2+ is a universal intracellular messenger, playing pivotal roles in nearly all biological processes. We combine state-of-the-art molecular imaging, single-channel patch clamping, electron microscopy and molecular cell biology techniques to dissect the molecular mechanisms underlying the generation, amplification and termination of intracellular Ca2+ dynamics, aiming to answer important questions about the function, development and dysfunction of heart cells.
Representative Peer-Reviewed Publications
1. Yang HQ, Wang LP, Gong Y, Fan XX, Zhu SY, Wang XT, Wang YP, Li LL, Xing X, Liu XX, Ji GS, Hou T, Zhang Y, Xiao RP, Wang SQ* (2019) β2-Adrenergic Stimulation Compartmentalizes β1 Signaling into Nanoscale Local Domains by Targeting the C-Terminus of β1-Adrenoceptors. Circulation Research, 124(9):1350-1359.
2. Wu L, Dong A, Dong LT, Wang SQ, Li YL (2019) PARIS, an optogenetic method for functionally mapping gap junctions. eLife, 8:e43366.
3. Zhao YT, Guo YB, Gu L, Fan XX, Yang HQ, Chen Z, Zhou P, Yuan Q, Ji G, Wang SQ (2017) Sensitized signaling between L-type Ca2+ channels and ryanodine receptors in the absence or inhibition of FKBP12.6 in cardiomyocytes. Cardiovascular Research, 113(3):332-342.
4. Xiao E, Yang H, Gan YH, Duan DH, He LH, Guo Y, Wang SQ*, Zhang Y* (2015) TRPM7 Senses Mechanical Stimulation Inducing Osteogenesis in Human Bone Marrow Mesenchymal Stem Cells. Stem Cells, 33(2):615-621.
5. Shang W, Lu F, Sun T, Xu J, Li LL, Wang Y, Wang G, Chen L, Wang X, Cannell MB, Wang SQ*, Cheng H* (2014) Imaging Ca2+ Nanosparks in Heart with a New Targeted Biosensor. Circulation Research, 114(3):412-420.【Circ. Res. commentary: Zhao YT & Valdivia. Ca2+ nanosparks: shining light on the dyadic cleft. Circulation Research】
6. Li RC, Tao J, Guo YB, Wu HD, Liu RF, Bai Y, Lv ZZ, Luo GZ, Li LL, Wang M, Yang HQ, Gao W, Han QD, Zhang YY, Wang XJ, Xu M, Wang SQ* (2013) In Vivo Suppression of MicroRNA-24 Prevents the Transition Toward Decompensated Hypertrophy in Aortic-Constricted Mice. Circulation Research, 112(4): 601-605.
7. Zhang HB, Li RC, Xu M, Xu SM, Lai YS, Wu HD, Xie XJ, Gao W, Ye H, Zhang YY, Meng X, Wang SQ* (2013) Ultrastructural Uncoupling between T-tubules and Sarcoplasmic Reticulum in Human Heart Failure. Cardiovascular Research, 98(2):269-276.
8. Xu M, Wu HD, Li RC, Zhang HB, Wang M, Tao J, Feng XH, Guo YB, Li SF, Lai ST, Zhou P, Li LL, Yang HQ, Luo GZ, Bai Y, Xi JZ J., Gao W, Han QD, Zhang YY, Wang XJ*, Meng X, and Wang SQ* (2012) MiR-24 regulates junctophilin-2 expression in cardiomyocytes. Circulation Research, 111(7):837-841.【Circ. Res. commentary: Song LS, et al. MicroRNA: a toolkit fine-tuning the dyadic `fuzzy space`? Circulation Research 111:816-818】
9. Wu HD, Xu M, Li RC, Guo L, Lai YS, Xu SM, Li ll, Lü QL, Zhang HB, Zhang YY, Zhang CM and Wang SQ* (2012) Ultrastructural Remodeling of Ca2+ Signaling Apparatus in Failing Heart Cells. Cardiovascular Research, 95(4):430-438.【Cardiovasc Res. commentary: Swift F, Christensen G. Calcium release units in heart failure: that`s about the size of it. Cardiovascular Research 95: 397-398】
10. Li XC, Wei L, Zhang GQ, Bai ZL, Hu YY, Zhou Z, Bai SH, Chai Z, Lakatta EG, Hao XM, Wang SQ* (2011) Ca2+ cycling in heart cells from ground squirrels: adaptive strategies for intracellular Ca2+ homeostasis. PLoS One, 6(9):e24787.
11. Guo YB, Wen Y, Gao WX, Li JC, Zhou P, Bai ZL, Zhang B and Wang SQ* (2010) The formation of Ca2+ gradients at the cleavage furrows during cytokinesis of Zebrafish embryos. Frontiers in Biology, 5(4):369-377.
12. Zhou P, Zhao YT, Guo YB, Xu SM, Bai SH, Lakatta EG, Cheng H, Hao XM, Wang SQ* (2009) Beta-Adrenergic signaling accelerates and synchronizes cardiac ryanodine receptor response to a single L-type Ca2+ channel. Proc. Natl. Acad. Sci. U. S. A. , 106(42):18028-18033.
13. Tang AH, Wang SQ* (2009) Transition of spiral calcium waves between multiple stable patterns can be triggered by a single calcium spark in a fire-diffuse-fire model. Chaos, 19(3):037114.
14. Xu M, Zhou P, Xu SM, Liu Y, Feng XH, Bai SH, Bai Y, Hao XM, Han QD, Zhang YY*, Wang SQ* (2007) Intermolecular Failure of L-type Ca2+ Channel and Ryanodine Receptor Signaling in Hypertrophy. PLoS Biology, 5(2): e21,0203-0211. 【Research Highlight: Harrison C （2007）Heart disease: Unmasking molecular mechanisms. Nature Reviews Drug Discovery 6: 271】
15. Zhou C, Tai C, Ye HH, Ren X, Chen JG, Wang, SQ*, Chai Z* (2006) Interleukin-1b downregulates the L-Type Ca channel activity by depressing the expression of channel protein in cortical neurons. Journal of Cellular physiology, 206(3):799-806.
16. Fu Y, Zhang GQ, Hao XM, Wu CH, Chai Z, Wang SQ* (2005) Temperature dependence and thermodynamic properties of Ca2+ sparks in rat cardiomyocytes. Biophysical Journal, 89(4):2533-2541.
17. Wang SQ, Stern MD, Ríos E, Cheng H (2004) The quantal nature of Ca2+ sparks and in situ operation of the ryanodine receptor array. Proc. Natl. Acad. Sci. U. S. A. , 101(11): 3979-3984.
18. Liao XD, Tang AH, Chen Q, Jin HJ, Wu CH, Chen LY, Wang SQ* (2003) Role of Ca2+ signaling in initiation of stretch-induced apoptosis in neonatal heart cells. Biochemical and Biophysical Research Communications, 310(2):405-411.
19. Wang SQ, Song LS, Xu L, Meissner G, Lakatta EG, Rios E, Stern MD, Cheng H* (2002) Thermodynamically irreversible gating of ryanodine receptors in situ revealed by stereotyped duration of release in Ca2+ sparks. Biophysical Journal, 83(1): 242-251.
20. Wang SQ ,Song LS, Lakatta EG, Cheng H (2001) Ca2+ signaling between single L-type Ca2+ channels and ryanodine receptors in heart cells. Nature, 410(6828):592-596.