using zebrafish (Danio rerio) as a
major animal model, we are interested in: (1) Genetic, cellular and molecular
mechanisms of vertebrate embryogenesis and organogenesis, as well as organ
regeneration, especially heart development and regeneration. (3) Functional
genomics study and technology development: Targeted genome modification/genome
editing through TALENs and CRISPR/Cas system; Single-cell transcriptomics. (3)
Modeling human diseases in zebrafish and dissecting the underlying genetic,
cellular and molecular mechanisms.