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Office Phone: 59743
Office Address: Integrated Science Research Center No.2,Peking University, No.5 Yiheyuan Road, Haidian District,Beijing, P.R.China 100871
Lab Phone: 59624
Lab Address: Integrated Science Research Center No.2,Peking University, No.5 Yiheyuan Road, Haidian District,Beijing, P.R.China 100871
Lab Homepage: http://
Personal Homepage: http://
Representative Peer-Reviewed Publications
1. Shuo Du, Yunlong Cao, Qinyu Zhu, Pin Yu, …… X Sunney Xie*, Xiao-dong Su*, Junyu Xiao*, Chuan Qin*. Structurally resolved SARS-CoV-2 antibody shows high efficacy in severely infected hamsters and provides a potent cocktail pairing strategy. Cell (2020) 183:1-11
2. Xu YP, Xu H, Wang B, Su XD*. Crystal structures of N-terminal WRKY transcription factors and DNA complexes. Protein & Cell (2020) 11, 208–213
3. Zhen Zhao, Zhixing Ma, Bo Wang,Yukun Guan, Xiao-Dong Su*,Zhengfan Jiang*.Mn2+ Directly Activates cGAS and Structural Analysis Suggests Mn2+ Induces a Noncanonical Catalytic Synthesis of 2′3′-cGAMP. Cell Reports 32 (7), 108053, August 18, 2020.
4. Kai Yu, Yuqiong Hu, Fan Wu, Qiufang Guo, Zenghui Qian, Waner Hu, Jing Chen, Kuanyu Wang, Xiaoying Fan, Xinglong Wu, John EJ Rasko, Xiaolong Fan, Antonio Iavarone*, Tao Jiang*, Fuchou Tang*, Xiao-Dong Su*. Surveying brain tumor heterogeneity by single-cell RNA sequencing of multi-sector biopsies. National Science Review (NSR) (2020) 7:1306-18.
5. Wang C, Guan Y, Lv M, Zhang R, Guo Z, Wei X, Du X, Yang J, Li T, Wan Y, Su X, Huang X, Jiang Z. “Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-Stranded DNA and Is Required for the Host Defense against DNA Viruses.” Immunity. (2018) pii: S1074-7613(18)30093-1. doi: 10.1016/j.immuni.2018.03.017.
6. Ming-jing Deng, Chao E, Jianli Tao, Zhao-yang Ye, Zhengfan Jiang, Jin Yu, Xiao-dong Su “Novel mechanism for cyclic di-nucleotide degradation revealed by structural studies of Vibrio phosphodiesterase V-cGAP3” (2018) JMB 430(24):5080-5093. doi: 10.1016/j.jmb.2018.10.010.
7. Lian TF, Xu YP, Li L, Su XD* “Crystal Structure of tetrameric Arabidopsis MYC2 reveals the mechanism of enhanced interaction with DNA” Cell Reports (2017) 19(7):1334-1342.
8. Jianli Tao, Xiao-Wei Zhang, Jianshi Jin, Xiao-Xia Du, Tengfei Lian, Jing Yang, Xiang Zhou, Zhengfan Jiang, and Xiao-Dong Su. Nonspecific DNA Binding of cGAS N Terminus Promotes cGAS Activation J. Immuno. (2017) 198(9):3627-3636. doi: 10.4049/jimmunol.1601909.
9. Jin JS, Lian TF, Gu C, Yu K, Gao YQ*, Su XD* “The effects of cytosine methylation on general transcription factors” (2016) Sci Rep.; 6:29119. doi:10.1038/srep29119.
10. Bajar BT, Lam AJ, Badiee RK, Oh YH, Chu J, Zhou XX, Kim N, Kim BB, Chung M, Yablonovitch AL, Cruz BF, Kulalert K, Tao JJ, Meyer T, Su XD, Lin MZ. “Fluorescent indicators for simultaneous reporting of all four cell cycle phases.” Nat Methods. (2016); 13(12):993-996. doi: 10.1038/nmeth.4045
11. Xiao-Jun Wang, Qin Cao, Yan Zhang and Xiao-Dong Su*, “Activation and Regulation of Caspase-6 and Its Role in Neurodegenerative Diseases”, Annu. Rev. Pharmacol. Toxicol., 2015; 55:553-72. doi: 10.1146/annurev-pharmtox-010814-124414.
12. Gao J, Tao J, Liang W, Zhao M, Du X, Cui S, Duan H, Kan B, Su X*, Jiang Z.* Identification and characterization of phosphodiesterases that specifically degrade 3'3'-cyclic GMP-AMP. Cell Res. 2015 May;25(5):539-50. doi: 10.1038/cr.2015.40.
13. Bao ZS, Chen HM, Yang MY, Zhang CB, Yu K, Ye WL, Hu BQ, Yan W, Zhang W, Akers J, Ramakrishnan V, Li J, Carter B, Liu YW, Hu HM, Wang Z, Li MY, Yao K, Qiu XG, Kang CS, You YP, Fan XL, Li RQ, Su XD, Chen CC, Jiang T. “RNA-Seq of 272 gliomas revealed a novel, recurrent PTPRZ-MET fusion transcript in secondary glioblastomas” Genome Research , Genome Research , 2014 , 24(11):1765-73
14. Qin Cao, Xiao-Jun Wang, Lan-fen Li and Xiao-Dong Su*, “The regulatory mechanism of caspase-6 pro-domain revealed by crystal structure and biochemical assays”, Acta Crystallogr Sect D Struct Biol. 2014 , 70(Pt 1):58-67.
15. Zixi Wang, Lanfen Li, Xiao-Dong Su*, Structure of human CLOCK-BMAL1 bHLH domains and DNA complex provides insights into protein-protein/DNA recognition and transcription control , Cell Res. , 2013 , 23(2):213-24.
16. Kim S, Broströmer E, Xing D, Jin J, Chong S, Ge H, Wang S, Gu C, Yang L, Gao YQ, Su XD*, Sun Y*, Xie XS*. , Probing allostery through DNA.” Science. , 2013 , 339(6121):816-9.
17. Ni X, Zhuo M, Su Z, Duan J, Gao Y, Wang Z, Zong C, Bai H, Chapman A, Zhao J, Xu L, An T, Ma Q, Wang Y, Wu M, Sun Y, Wang S, Li Z, Yang X, Yong J, Su XD, Lu Y, Bai F*, Xie XS*, and Wang J*, “Reproducible Copy Number Variation Patterns among Single Circulating Tumor Cells of Lung Cance Patients”, PNAS 110(2013), 2013, pp21083-21088.
18. Huang YH, Liu XY, Du XX, Jiang ZF & Su XD* “The Structural Basis for the Sensing and Binding of Cyclic di-GMP by STING” (2012) Nature Structural & Molecular Biology, 219(7):728-30. doi: 10.1038/nsmb.2333.
19. Xiao-Jun Wang, Xiang Liu, Kai-Tuo Wang, Wei Mi, Yan Zhang, Lan-Fen Li, Andrea C. LeBlanc*, Xiao-Dong Su* “Crystal structures of human caspase-6 reveal a novel intramolecular cleavage self-activation mechanism” (2010) EMBO Rep. 11(11):841-7. Epub 2010 Oct 1.
20. Ming-Rui Duan, Jie Nan, Yu-He Liang, Peng Mao, Lu Lu, Luhua Lai, Yi Li, and Xiao-Dong Su , DNA Binding Mechanism Revealed by High Resolution Crystal Structure of Arabidopsis thaliana WRKY1 Protein , Nucleic acid research , 2007 , 35(4):1145-54
21. Brostromer E, Nan J. and Su XD , An automated image-collection system for crystallization experiments using SBS standard microplates , Acta Crystallogr D Biol Crystallogr., 2007, 63:119-25
22. Su XD, Liang Y, Li L, Nan J, Brostromer E, Liu P, Dong Y, Xian D , A large-scale, high-efficiency and low-cost platform for structural genomics studies , Acta Crystallogr D Biol Crystallogr , 2006 , 62(8):843-51
23. Yu Y, Liang YH, Brostromer E, Quan JM, Panjikar S, Dong YH, Su XD , A catalytic mechanism revealed by the crystal structures of the imidazolonepropionase from Bacillus subtilis , J. Biol. Chem. , 2006 , 281(48):36929-36
24. Hui Ren, Liya Wang, Matthew Bennett, Yuhe Liang, Xiaofeng Zheng, Fei Lu, Lanfen Li, Jie Nan, Ming Luo, Staffan Eriksson, Chuanmao Zhang, and Xiao-Dong Su , The Crystal Structure of human Adenylate Kinase 6: An Adenylate Kinase Localized to the Cell Nucleus , Proc. Natl. Acad. Sci. USA (PNAS) , 2005 , 102:303-308
25. Marcia Alvarez-Fernandez, Yuhe Liang, Magnus Abrahamson and Xiao-Dong Su, Crystal structure of human cystatin D, a cysteine peptidase inhibitor with restricted inhibition profile, J. Biol. Chem. , 2005 , 280:18221-18228
26. Selmer, M.; and Su, X.-D., Crystal structure of an mRNA binding fragment of Moorella thermoacetica SelB , EMBO J. , 2002 , 21(15):4145-53
27. Bennett, M.; Guan, Z.; Laurberg M. and Su, X-D, Bacillus subtilis arsenate reductase is structurally and functionally similar to low molecular-weight protein tyrosine phosphatases , Proc. Natl. Acad. Sci. USA (PNAS) , 2001 , 98:13577-13582

Laboratory Introduction