Home /
LI, Yi
Office Address: Jinguang Life Science Building,Peking University, No.5 Yiheyuan Road, Haidian District,Beijing, P.R.China 100871
Lab Phone: 62759651
Lab Address: Jinguang Life Science Building,Peking University, No.5 Yiheyuan Road, Haidian District,Beijing, P.R.China 100871
Lab Homepage: http://
Personal Homepage: http://
Professional Experience
1979-1983 B.S, Northwest Sci-Tech University of Agriculture and Forestry
1983-1986 M.S, Northwest Sci-Tech University of Agriculture and Forestry
1988-1992 Ph.D, The Institute for Biochemistry and Plant Virology, Germany / Institute of Microbiology Chinese Academy of Sciences
1992-1994 Postdocotor fellow, Peking University, College of Life Sciences
2001-2003 Visiting Scholar, University of California, Berkeley.

Editorial Activities
Phytopathology Research, Associate editor (2019-今);
Virologica Sinica, Associate editor (2012-今);
Frontier in Plant Science, Associate editor (2014-今);
Molecular Plant-microbe Interactions (MPMI), Senior editor (2019-今)。
Grant Review/Study Section Membership
National Natural Science Foundation of China, Natural Science Foundation (US), Canadian Agricultural and Food Adminstartion.
Meeting Organizers and Session Chairs
1. XVII Molecular Plant and Microbial Interactions (MPMI) Congress, Co-chair, Concurrent Session 17 (Microbial Manipulation of the Host II). Title: Small RNA mediated Antiviral Defense in Rice. July, 17-21, 2016, Portland, Oregon, USA.
2. XIV International Botany Congress,IBC, 2017 July,Co-chair:Microbial - Host Interactions, Title: MicroRNA Mediated Plant Antiviral Defense,Shenzhen, China.
Books and Book Chapter

Huang Y & Li Y. Chapter 00436, Plant Reoviruses (Reoviridae), Encyclopedia of Virology 4th edition, edited by Fauquet Claude M, 2019.
现代分子生物学,高教出版社,朱玉贤,李毅等,2007, 第三版。
Research Interests
Research Fields:

Current projects focus on virus–host interactions and structural studies on host factors involved in virus-host interaction and plant defense against pathogens. These projects fall into several specific topics:
1. Interactions between host genes and genes from viruses and disease induction;
2. Virus induced gene silencing and silencing suppression;
3. Screening of antiviral compounds from medicinal plants and their mechanism against virus infection;
4. Structural studies on host factors involved in virus-host interaction and plant defense against pathogens.
Representative Peer-Reviewed Publications
1. *Yang Z, Huang Y, Yang J, Yao S, Zhao K, Wang D, Qin Q, Bian Z, Li Y, Lan Y, Zhou T, Wang H,
Liu C, Wang W, Qi Y, Xu Z, and Li Y. Jasmonate signaling enhances RNA silencing and
antiviral defense in rice. Cell Host & Microbe. In Press.(通讯作者)
2. *Wang Y, Qiao R, Wei C, Li Y. Rice dwarf virus small RNA profiles in rice and leafhopper
reveal distinct patterns in cross-kingdom hosts. Viruses. 2019, 11,847:1-12.
3. *Gao F, Zhao S, Men S, Kang Z, Hong J, Wei C, Hong W, Li Y. A Non-structural Protein Encoded
by Rice Dwarf Virus Targets to the Nucleus and Chloroplast and Inhibits Local RNA Silencing.
Science in China, Life Science.http://doi.org/10.1007/s11427-019-1648-3.(通讯作者)
4. Huang Y., and Li Y. 2018. Secondary siRNAs rescue virus-infected plants Nature Plants, 4:
136-137. (Invited review)(通讯作者)
5. Yang Z., and Li Y. 2018. Dessection of RNAi-based antiviral immunity in plants. Current
Opinion in Virology, 32: 88-99.(Invited review)(通讯作者)
6. Zhao S, Hong W, Wu J, Wang Y, Ji S, Zhu S, Wei C, Zhang J, Li Y. 2017. A viral protein
promotes host SAMS1 activity and ethylene production for the benefit of virus infection.
eLife, 6. e27529. (通讯作者)
7. Zheng L, Zhang C, Shi C, Yang Z, Wang Y, Zhou T, Sun F, Wang H, Xie L., Wu J., Li Y. 2017.
Rice stripe virus NS3 protein regulates primary miRNA processing through association with
the miRNA biogenesis factor OsDRB1 and facilitates virus infection in rice. PLoS Pathogens,
13(10): e1006662.(共同通讯作者)
8. Jia D, Mao Q, Chen Y, Liu Y, Chen Q, Wu W, Zhang X, Chen H, Li Y., Wei T. 2017. Insect
symbiotic bacteria harbours viral pathogens for transovarial transmission. Nature
Microbiology. 2: 17025.(共同通讯作者)
9. Wu J, Yang R, Yang Z, Yao S, Zhao S, Wang Y, Li P, Song X, Jin L, Zhou T, Lan Y, Xie L, Zhou
X, Chu C, Qi Y., Cao X., and Li Y. ROS accumulation and antiviral defence control by
microRNA528 in rice. Nature Plants, 2017, 3: 16203.(引用:0)(共同通讯作者)
10. Jin L, Qin Q, Wang Y, Liu L, Wen X, Ji S, Wu J, Wei C, Ding B, Li Y*. A Viral Protein
Blocks Initiation of Auxin Signaling to Enhance Viral Pathogenesis. PLoS Pathogens, 2016, 12
(9): e1005847.
11. Wei T and Li Y. Rice Reoviruses in Insect Vectors. Ann Rev Phytopathol 54, 99-120, 2016.
12. Wu J#, Yang Z#, Wang Y, Xie L, Cao X, Wu Z*, Qi Y*, Li Y*. Viral-Inducible Argonaute18
Confers Broad-Spectrum Virus Resistance in Rice by Sequestering A Host MicroRNA. eLife
2015;4e:05733. DOI: 10.7554/eLife.05733.(共同通讯作者)
13. Cao M#, Du P# Wang X, Li W, Gal-On A, Zhou CY , Li Y*, Ding SW*. Virus infection triggers
widespread silencing of host genes by a distinct class of endogenous siRNAs in Arabidopsis.
PNAS, USA,September 8, 2014, doi:10.1073/ pnas. 1407131111.(共同通讯作者)
Molecular Virology
Laboratory Introduction