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KONG, Daochun
Title:
Professor
Office Phone: 62760866
Office Address: Jinguang Life Science Building,Peking University, No.5 Yiheyuan Road, Haidian District,Beijing, P.R.China 100871
Lab Phone: 62767127
Lab Address: Jinguang Life Science Building,Peking University, No.5 Yiheyuan Road, Haidian District,Beijing, P.R.China 100871
Lab Homepage: http://
Personal Homepage: http://
Resume
Biography
Curriculum Vitae


Daochun Kong


Degrees B.S. Lanzhou University, 1983
M.S. Shanghai Institute of Biochemistry, Chinese Academy of Science, 1989
Ph.D. Temple University Medical School, USA. 1995


Professional Training

1979-1983 Lanzhou University
1986-1989 Graduate Student, Shanghai Institute of Biochemistry, Chinese Academy of Science
1990-1995 Graduate Student, Department of Biochemistry, Temple University Medical School
1995-1998 Postdoctoral Fellow, Department of Biological Chemistry and Molecular
Pharmacology, Harvard Medical School
1998-2000 Postdoctoral Fellow, The Memorial Sloan-Kettering Cancer Center


Employment

1983-1986 Research Fellow, Lanzhou Institute of Biomedicine, China
1989-1990 Head, The Group of Protein Purification, Shanghai Academy of Biomedicine, China


Academic Appointments

2000-2005 Research scientist, National Institutes of Health, U.S.A
2005- Professor, The National Laboratory of Protein Engineering and Plant Genetic
Engineering, The College of Life Sciences, Peking University, China
2012- Investigator, Peking-Tsinghua Center for Life Sciences

Education
Professional Training

1979-1983 Bachelor, Lanzhou University
1986-1989 Master, Graduate Student, Shanghai Institute of Biochemistry, Chinese Academy
of Science
1990-1995 Doctor, Graduate Student, Department of Biochemistry, Temple University
Medical School
1995-1998 Postdoctoral Fellow, Department of Biological Chemistry and Molecular
Pharmacology, Harvard Medical School
1998-2000 Postdoctoral Fellow, The Memorial Sloan-Kettering Cancer Center
Representative Peer-Reviewed Publications
1. Ling Guan*, Peng He*, Fang Yang*, Yuan Zhang*, Yunfei Hu*, Jienv Ding*, Yu Hua, YiZhang, Qiong Ye, Jiazhi Hu1, Tao Wang§, Changwen Jin§, Daochun Kong§, Sap1 is a replication initiation factor essential for the assembly of pre-replicative complex in the fission yeast Schizosaccharomyces pombe. J Biol Chem. 2017 Apr 14;292(15):6056-6075. doi: 10.1074/jbc.M116.767806. Epub 2017 Feb 21. (cover article)

2. Bochao Liu, Jiazhi Hu, Jingna Wang, Daochun Kong, Direct Visualization of RNA-DNA Primer Removal from Okazaki Fragments Provides Support for Flap Cleavage and Exonucleolytic Pathways in Eukaryotic Cells. 2017 Mar 24;292(12):4777-4788. doi: 10.1074/jbc.M116.758599. Epub 2017 Feb 3.

3. Huimin Zhang, Yu Hua, Rui Li, Daochun Kong, Cdc24 Is Essential for Long-range End Resection in the Repair of Double-stranded DNA Breaks. J Biol Chem. 2016 Nov 25;291(48):24961-24973.

4. Ming Zeng, Laifeng Ren, Ken`Ichi Mizuno, Konstantinos Nestoras, Haibin Wang, Zizhi Tang, Liandi Guo, Daochun Kong, Qiwen Hu, Qun He, Lilin Du, Antony M. Carr, and Cong Liu, CRL4(Wdr70) regulates H2B monoubiquitination and facilitates Exo1-dependent resection. Nat Commun. 2016 Apr 21;7:11364.

5. Lihong Wu, Yang Liu, Daochun Kong, Mechanism of chromosomal DNA replication initiation and replication fork stabilization in eukaryotes. Sci China Life Sci. 2014 May;57(5):482-7. Review.

6. Jiazhi Hu, Lei Sun, Fenfen Shen, Yufei Chen, Yu Hua, Yang Liu, Mian Zhang, Yiren Hu, Qingsong Wang, Wei Xu, Fei Sun, Jianguo Ji, Johanne M. Murray, Antony M. Carr, and Daochun Kong, The intra-S phase checkpoint targets Dna2 to prevent stalled replication forks from reversing, Cell, 2012, 149(6):1221-32.
Laboratory Introduction