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JIANG, Zhengfan
E-mail: jiangzf(AT)pku.edu.cn
Office Address: Jinguang Life Science Building,Peking University, No.5 Yiheyuan Road, Haidian District,Beijing, P.R.China 100871
Lab Address: Jinguang Life Science Building,Peking University, No.5 Yiheyuan Road, Haidian District,Beijing, P.R.China 100871
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Professional Experience
Sept. 2011-Present, Investigator, Peking-Tsinghua Center for Life Sciences
Sept. 2006-Present, Professor, Peking University, China
Sept. 2003-Sept. 2006, Research Associate, Department of Immunology, The Scripps Research Institute, La Jolla, CA, USA
Jul. 1999-Sept.2003, Research Associate,Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA
Sept. 1997-Jul. 1999, Postdoctoral Fellow, College of Life Sciences, Peking University, China
Social Services
1. 2010-至今, 国家自然科学基金委专家组成员, 国家自然科学基金委
2. 2010-2017, 国家自然科学基金委重大研究计划专家组成员, 国家自然科学基金委
Honors and Awards
Professional Society Affiliations
Grant Review/Study Section Membership
1. 2010-至今, 国家自然科学基金委专家组成员, 国家自然科学基金委
2. 2010-2017, 国家自然科学基金委重大研究计划专家组成员, 国家自然科学基金委
Representative Peer-Reviewed Publications
1. Fang R, Jiang Q, Guan Y, Gao P, Zhang R, Zhao Z, and Jiang Z*. 2021, Golgi-synthesized sulfated glycosaminoglycans mediate polymerization and activation of the cGAMP sensor STING. Immunity, 54: 962–975.
2. Yu X, Zhang L, Shen J, Zhai Y, Jiang Q, Yi M, Deng X, Ruan Z, Fang R, Chen Z, Ning X, Jiang Z*. 2021, The STING Phase-separator Suppresses Innate Immune Signaling. Nature Cell Biology, 23: 330-340.
3. Zhang R, Wang C, Guan Y, Wei X, Sha M, Jing M, Lv M, Guo W, Xu J, Wan Y, Jia X, Jiang Z*. 2021, Manganese salts function as potent adjuvants. Cellular & Molecular Immunology, 18: 1222–1234.
4. Lv M. Chen M, Zhang R, Zhang W, Wang C, Zhang Y, Wei X, Guan Y, Liu J, Feng K, Jing M, Wang X, Liu Y, Mei Q*, Han W*, Jiang Z*. 2020, Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy. Cell Research, 30: 966–979.
5. Zhao Z. Ma Z., Wang B, Guan Y, Su X*, Jiang Z*. 2020, Mn2+ Directly Activates cGAS and Structural Analysis Suggests Mn2+ Induces A Noncanonical Catalytic Synthesis of 2`3`-cGAMP. Cell Reports, 32(7): 108053.
6. Ning X, Wang Y, Jing M, Sha M, Lv M, Gao P, Zhang R, Huang X, Feng J, Jiang Z*. 2019, Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS and IRF3. Molecular Cell, 74: 1-13.
7. Wang C, Guan Y, Lv M, Zhang R, Guo Z, Wei X, Du X, Yang J, Li T, Wan Y, Su X, Huang X, Jiang Z*. 2018, Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-stranded DNA and Is Required for the Host Defense against DNA Viruses. Immunity, 48: 675-687.
8. Wang Y, Ning X, Gao P, Wu S, Sha M, Lv M, Zhou X, Gao J, Fang R, Meng G, Su X, Jiang Z*. 2017, Inflammasome activation triggers caspases-mediated cleavage of cGAS to regulate responses to DNA virus infection. Immunity, 46: 393-404.
9. Chen H, Sun H, You F, Sun W, Zhou X, Chen L, Yang J, Wang Y, Tang H, Guan Y, Xia W, Gu J, Ishikawa H, Gutman D, Barber G, Qin Z, Jiang Z*. 2011, Activation of STAT6 by STING is Critical for Antiviral Innate Immunity. Cell, 147: 436-446.
10. You FP, Sun H, Zhou X, Sun WX, Liang SM, Zhai ZH & Jiang Z*. 2009, PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4. Nature Immunology, 10: 1300-1308.
11. Sun W, Li Y, Chen L, Chen H, You F, Zhou X, Zhou Y, Zhai Z, Chen D, Jiang Z*. 2009, ERIS, an ER IFN stimulator, activates innate immune signaling through dimerization. PNAS, 106: 8653-8.
12. Gao J, Tao J, Liang W, Zhao M, Du X, Cui S, Duan H, Kan B, Su X, Jiang Z*. 2015, Identification and characterization of phosphodiesterase V-cGAPs that specifically degrade 3`3`-cyclic GMP-AMP. Cell Research, 25: 539-550.
13. Fang R, Jiang Q, Zhou X, Wang C, Guan Y, Tao J, Xi J, Feng J, Jiang Z*. 2017, MAVS activates TBK1 and IKKb through TRAFs in NEMO dependent and independent manner. PLoS Pathogens, 13(11): e1006720.
14. Fang R, Lin Y, Zhou X, Wang C, Guan Y, Tao J, Xi J, Feng J, Jiang Z*. 2017, NEMO-IKKβ Are Essential for IRF3 and NF-κB Activation in the cGAS-STING Pathway. J Immunology, 199: 3222-3233.
15. Tao J, Zhang X, Jin J, Du X, Lian T, Yang J, Zhou X, Jiang Z*, Su X*, 2017, Non-specific DNA binding by N-terminal domain promotes activation of human cyclic GMP-AMP synthase. J Immunology, 198: 3627-3636.
16. Gao J, Tao J, Liang W, Jiang Z*. 2016, Cyclic (di)nucleotides: the common language shared by Microbe and Host. Current Opinion in Microbiology, 30: 79–87.
17. Huang YH, Liu XY, Du XX, Jiang Z, Su XD*. 2012, The structural basis for the sensing and binding of cyclic di-GMP by STING. Nat Struct Mol Biol., 19: 728-30.
18. Zhou X, You F, Chen H, Jiang Z*. 2012, Poly(C)-binding protein 1 mediates house-keeping degradation of mitochondrial antiviral signaling (MAVS). Cell Research, 22: 717-727.
19. Xiao H, Qian W, Staschke K, Qian Y, Cui G, Deng L, Ehsani M, Wang X, Qian YW, Chen ZJ, Gilmour R, Jiang Z*, Li X*. 2008, Pellino 3b negatively regulates interleukin-1-induced TAK1-dependent NF kB activation. J Biol Chem., 283: 14654-64.
20. Jiang Z, Georgel P, Li C, Choe J, Crozat K, Rutschmann S, Du X, Bigby T, Mudd S, Sovath S, Wilson I A, Olson A, Beutler B. 2006, Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis. PNAS, 103: 10961-66.
21. Jiang Z, Georgel P, Du X, Shamel L, Sovath S, Mudd S, Huber M, Kalis C, Keck S, Galanos C, Freudenberg M, Beutler B. 2005, CD14 is required for MyD88-independent LPS signaling. Nature Immunology, 6: 565-70.
22. Jiang Z, Mak TW, Sen G, Li X. 2004, Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta. PNAS, 101: 3533-8.
23. Jiang Z, Zamanian-Daryoush M, Nie H, Silva AM, Williams BR, Li X. 2003 Poly (I-C)-induced TLR3-mediated activation of NFkappa B and MAP kinase is through an IRAK-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR. J Biol Chem., 278: 16713-9.
24. Jiang Z, Johnson HJ, Nie H, Qin J, Bird TA, Li X. 2003, Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IRAK4-IRAK-TRAF6 complex. J Biol Chem., 278: 10952-6.
25. Jiang Z, Ninomiya-Tsuji J, Qian Y, Matsumoto K, Li X. 2002, Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol. Mol Cell Biol., 22: 7158-67.
26. Beutler B, Jiang Z, Georgel P, Crozat K, Croker B, Rutschmann S, Du X and Hoebe K, 2006, Genetic Analysis of Host Resistance: Toll-like Receptor Signaling and Immunity at Large. Annual Review of Immunology, 24: 353-89.
Laboratory Introduction
Laboratory Phone:62767578