题目：Ciliary PI(4,5)P2 dictates fall of primary cilia and rise of cell cycle
讲座人： Takanari Inoue，Ph.D.
Department of Cell Biology
Johns Hopkins University School of Medicine
时间：2017年4月28日，13:00 - 14:30
A primary cilium is presented as a meso-scale device that senses and translates extracellular information into intracellular biochemical reactions. These input cues manifest in a variety of forms ranging from chemical to mechanical ones. Deregulation of these information transfer leads to human diseases known as ciliopathies. Due to its diffraction-limited dimension and semi-membrane-bound topology, a primary cilium has been a daunting compartment to visualize and manipulate signaling events on site. To overcome this challenge, we combine a chemically inducible dimerization technique with specific organelle targeting to achieve rapidly inducible manipulation of signal transduction exclusively inside primary cilia. We will discuss our recent published as well as unpublished works on roles of actin, tubulins and phosphoinositides in stability of primary cilia.